CD8 Lineage Commitment in the Absence of CD8
نویسندگان
چکیده
منابع مشابه
CD4/CD8 lineage commitment: back to instruction?
M echanisms o f lineage commitment are o f considerable interest in biology, and lineage commitment in the immune system represents no exception to this rule. In the thymus, the T C R ot/[3 lineage diverges into the CD4+8 and C D 4 8 + lineages, which exhibit distinct functional programs after antigenic stimulation. To a large extent, these programs are fixed before antigenic stimulation (1-5) ...
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Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. Nor has it been established whether the same genes regulate MHC expression and T cell selection. Here, we assessed the impact of natural genetic variation on MHC expression and CD4∶...
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A system to innocuously visualize T cell lineage commitment is described. Using a "knock-in" approach, we have generated mice expressing a beta-galactosidase reporter in place of CD4; expression of beta-galactosidase in these animals appears to be an accurate and early indicator of CD4 gene transcription. We have exploited this knock-in line to trace CD4/CD8 lineage commitment in the thymus, av...
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Lineage commitment is a developmental process by which individual CD4+CD8+ (double positive, DP) thymocytes make a decision to differentiate into either CD4+ or CD8+ T cells. However, the molecular event(s) that defines lineage commitment is controversial. We have previously proposed that lineage commitment in DP thymocytes can be molecularly defined as the selective termination of CD4 or CD8 c...
متن کاملTOX Provides a Link Between Calcineurin Activation and CD8 Lineage Commitment
T cell development is dependent on the integration of multiple signaling pathways, although few links between signaling cascades and downstream nuclear factors that play a role in thymocyte differentiation have been identified. We show here that expression of the HMG box protein TOX is sufficient to induce changes in coreceptor gene expression associated with beta-selection, including CD8 gene ...
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ژورنال
عنوان ژورنال: Immunity
سال: 1997
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80351-9